Heart disease is the leading cause of death in the United States, taking the life of one person every 33 seconds. Considering this terrifying statistic, it’s more important than ever to prioritize your heart health, particularly if you have a family history of coronary artery disease.
Many steps you can take to improve your heart health involve your lifestyle: eat a healthy diet rich in fruits and vegetables, reduce your stress, get plenty of quality sleep, and exercise regularly. But what if there was an additional, easy way to reduce your risk for heart disease while improving your overall quality of life?
Thanks to promising research, 1-MNA has become a popular supplement for adults who want to support their cardiovascular system and heart health. In this blog, we’ll explore what 1-MNA is, why some medical professionals recommend it for long-term heart health, and whether it’s right for you.

What Is 1-MNA & How Does It Work?
1-MNA, which stands for 1-methyl nicotinamide, is a molecule naturally produced when the body breaks down vitamin B3. 1-MNA’s primary function is to ensure vascular endothelial cell processes work smoothly and effectively. These endothelial cells line our blood vessels, guide blood throughout the body, and keep the entire vascular network functioning at its full potential.
Problems with the endothelial cells leave the body vulnerable to cardiovascular issues, including heart attacks. But the issues don’t stop there. Dysfunctions with endothelial cells also impact other organ systems in the body, potentially leading to diabetes, gastrointestinal disorders, liver problems, and kidney disease.
A significant way 1-MNA supports endothelial cell functioning is by stimulating the production of prostacyclin (PG12), a natural coagulant and anti-atherosclerotic. PG12 keeps platelets from clumping together and forming clots that can block arteries. PG12 is also believed to help decrease inflammation throughout the body.

1-MNA: A Cutting-Edge Molecule With Promising Heart & Health Benefits
Research on 1-MNA has been ongoing and promising for decades. 1-MNA is recommended for supporting the health of the cardiovascular and vascular systems. However, it has been found to have additional effects as well.
1-MNA supports the function of cell mitochondria and lowers the production of inflammation-producing compounds in the blood, making it a potential option for supporting the treatment of autoimmune diseases like Crohn’s, asthma, Type 1 Diabetes, lupus, and arthritis.
1-MNA’s anti-inflammatory and anticoagulant effects are believed to be beneficial for patients with long-lasting fatigue and low exercise tolerance following COVID-19.
One study even found that the immune-regulating properties of 1-MNA could be a possibility in treating certain kinds of cancer.
A study using nematodes has found that 1-MNA supplements may even extend lifespan.

Who Is A Good Candidate For 1-MNA Supplements?
As with any supplement, the big question is: What are the side effects?
The EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) evaluated the safety of 1-MNA supplements in 2017. They concluded that 1-MNA is typically safe under proposed uses and levels, and was unlikely to result in adverse health outcomes.
1-MNA is generally well tolerated. You should discuss starting 1-MNA supplementation with a trusted physician before getting started. Women who are breastfeeding or pregnant are not good candidates.

The Best 1-MNA Supplement Option? We Recommend Endotelio
1-MNA is found naturally in these sources, though in smaller amounts:
- Wakame seaweed: 3.2 mg per 100g
- Green tea leaves: 3.0 mg per 100g
- Chicken gizzards: 2.4 mg per 100g
- Celery: 1.6 mg per 100g
- Chinese black mushrooms: 1.3 mg per 100g.
For best results, you’ll want to take around 50 mg of 1-MNA. This can make supplementing through diet difficult. As a result, supplements are typically the best way to get the most benefits from 1-MNA.
Not all supplement brands are safe, effective, and worth the money. Our patients have the best results using Endotelio 1-MNA. Produced in Poland, Endotelio 1-MNA is vegan and free of nuts, gluten, and lactose. While we often recommend “Made in America” products, Endotelio 1-MNA has the research and quality assurance to make it a great option.
The product is synthesized using a unique technology developed in collaboration with top European universities. It is EFSA-approved, manufactured in a GMP-certified facility, and recognized with awards for its groundbreaking contribution to cellular health.
HOW MUCH DOES ENDOTELIO 1-MNA COST?
Protect Your Heart, Arteries, & Life Longevity
If you are concerned about the future of your heart health, there’s something you can do about it. 1-MNA supplements are a simple way to support your cardiovascular and vascular systems while improving your overall quality of life.
If you have questions about whether 1-MNA is right for you or would like to discuss a custom health plan to reduce your risk even further, schedule an appointment with The Resurge Clinic today. We understand how scary heart disease can be, and we’ll do everything we can to help you live with a lower risk and greater peace of mind.


